Development of a novel community-based high-performance surveillance network for drug use
An innovative, interdisciplinary research program that integrates epidemiology, community engagement, biostatistics, econometrics, and information dissemination to create a novel community-based, high performance surveillance network for people who use drugs (PWUD).
Strategies to reduce serious bacterial infections and overdose among people who inject drugs (ReDUCE)
A simulation model that projects long-term injection-related bacterial infections and assesses the long-term clinical impact of novel hospital-based interventions that directly treat or modify risk associated with the underlying opioid use disorder (OUD).
The Health Impacts of Felonizing Fentanyl Possession
A study of the health effects, including overdose and initiation and retention on medications for opioid use disorder (MOUD), of criminal penalties for synthetic opiates and felonizing fentanyl possession to evaluate how criminal penalties differentially affect marginalized populations and to understand how to ensure that future policy changes are centered on perspectives of people with lived experience.
improving Health and Housing Outcomes through a Simulation and Economic Model (iHOUSE)
An agent-based model that simulates the dynamic processes contributing to HIV incidence, overdose, and life expectancy among people along the housing and homelessness continuum of care in Denver, CO and San Francisco, CA to investigate potential combinations of HIV and substance use service delivery programs that are most beneficial for improving health outcomes.
In pursuit of a one-stop shop: a type 1 hybrid effectiveness-implementation trial of comprehensive tele-harm reduction for people who inject drugs (CHARIOT)
A study to determine if the comprehensive tele-harm reduction (C-THR) model increases engagement in HIV prevention compared to offsite referral and peer navigation, to examine the long-term clinical and cost-effectiveness of the C-THR model, and to assess the implementation and scalability of the C-THR model in diverse syringe service program (SSP) settings.
Transforming the evidence base on estimating prevalence of opioid use disorder and expanded access to interventions to prevent drug related deaths: an international data linkage study (TRANSFORM)
A first of its kind multi-jurisdictional study using data linkages in the US (Rhode Island, Colorado, Massachusetts, and Wisconsin), Australia (New South Wales), and the United Kingdom (UK; Scotland) to transform the evidence base on the prevalence of opioid use disorder (OUD) and the impact of opioid agonist therapy (OAT) as a strategy to prevent opioid harm.
MassHEAL – Reducing overdose deaths by 40%
A study to implement and evaluate an intervention targeting overdose fatalities in 16 highly-affected Massachusetts communities via a cluster-randomized parallel group design. The primary study outcome is number of overdose fatalities.
Caring for Denver
The ReDUCE model will be used to estimate the long-term societal impacts of providing wraparound substance use services to unhoused Denverites. Specifically, this evaluation will examine Peer Services and Medications for Opioid Use Disorder (MOUD) programs funded by Caring for Denver.
The Missing Us 